Cureus, Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder

Bipolar disorder (BD) and borderline personality disorder (BPD) share many behavioral features, such as periods of marked affective lability and instability. Although there is a symptomatic overlap, the two disorders may be differentiated based on longitudinal course, phenomenology, and treatment responsiveness. In addition, the emotional changes in BPD are generally influenced by interpersonal factors, whereas BD episodes tend to be more sustained. We performed a literature review on the structural MRI features of both disorders and compared the findings. There are differences in areas of white and gray matter volumes and thickness in BP and BPD. BPD primarily affects the fronto-limbic network, in particular, the amygdala, hippocampus, and orbitofrontal cortex, whereas BP affects both cortical and subcortical areas. There are a limited number of large studies, and many studies examined in this review did not adjust for confounding factors or motion artifacts, which limit the utility of current data.

Abnormalities in Cortical Gray Matter Density in Borderline Personality Disorder, European Psychiatry

Mirror neuron activations in encoding of psychic pain in borderline personality disorder - ScienceDirect

Common and distinct patterns of gray matter alterations in borderline personality disorder and posttraumatic stress disorder: A dual meta-analysis - ScienceDirect

Microstructural white matter alterations and personality traits: A diffusion MRI study - ScienceDirect

PDF] Neuroimaging and genetics of borderline personality disorder: a review.

Emotion dysregulation, impulsivity and anger rumination in borderline personality disorder: the role of amygdala and insula

Childhood trauma, midbrain activation and psychotic symptoms in borderline personality disorder

Common and distinct patterns of grey matter alterations in borderline personality disorder and bipolar disorder: voxel-based meta-analysis, The British Journal of Psychiatry

Cureus

Cortical haemodynamic response during the verbal fluency task in patients with bipolar disorder and borderline personality disorder: a preliminary functional near-infrared spectroscopy study, BMC Psychiatry

Cureus, Chondrosarcoma of Sternal Origin: A Rare Case

Cortical haemodynamic response measured by functional near infrared spectroscopy during a verbal fluency task in patients with major depression and borderline personality disorder - eBioMedicine

GoodTherapy Therapy Changes Brains of People with Borderline Personality

Structural brain abnormalities in borderline personality disorder correlate with clinical severity and predict psychotherapy response